結論

胃腸道pH值和緩沖容量的種間差異是重要的考慮因素，尤其是對胃腸道給藥的pHresponsive配方和可電離藥物。 因此，兔子和豬的空腸、回腸和近端結腸具有相對較高的緩沖容量，而豬遠端結腸具有較低的緩沖容量是非常重要的考慮因素。 與人相比，大鼠、兔和豬的近端小腸和升結腸的液體的滲透壓和表面張力也較高。 胃腸道特征的這些差異導致潑尼松龍在大鼠體內(nèi)的溶解度較高（近端結腸除外），而潑尼松龍在豬和兔體內(nèi)的溶解度與人類相當。 因此，如果在大鼠的體液中測量，中性化合物潑尼松龍的溶解度可能被高估。 另一方面，可電離藥物美沙拉秦在兔和豬體內(nèi)的溶解度在小腸中部高于人，在結腸中低于人，僅在小腸遠端與人相當。 胃腸道環(huán)境的差異，如pH值、緩沖容量、滲透壓和表面張力，導致藥物溶解度的差異。 在兔子和豬中，美沙拉秦的溶解度在沿胃腸道向下移動時發(fā)生顯著變化，這在很大程度上受管腔液的pH值和滲透壓的影響。

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Delta-8 動物胃腸道體內(nèi)中藥物的溶解度的測定——摘要、介紹

Delta-8 動物胃腸道體內(nèi)中藥物的溶解度的測定——材料和方法

Delta-8 動物胃腸道體內(nèi)中藥物的溶解度的測定——結果和討論

Delta-8 動物胃腸道體內(nèi)中藥物的溶解度的測定——結論、致謝！